靶标：
Ubr1
产品别名：
AI504731； Ubr1； ubiquitin protein ligase E3 component n-recognin 1； ubiquitin protein ligase E3 component n-recognin 1； E3 ubiquitin-protein ligase UBR1； E3 alpha； N-recognin-1； RING-type E3 ubiquitin transferase UBR1； ubiquitin-protein ligase E3-alpha-1； ubiquitin-protein ligase E3-alpha-I； ubiquitin-protein ligase e3 componen n-recognin；
背景信息：
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008],
