靶标:
Ppp1r13b
产品别名:
AI449786; ASPP1; AW545810; Tp53bp2; Trp53bp2; p85; Ppp1r13b; protein phosphatase 1, regulatory subunit 13B; protein phosphatase 1, regulatory subunit 13B; apoptosis-stimulating of p53 protein 1; protein phosphatase 1, regulatory (inhibitor) subunit 13B; transformation related protein 53 binding protein 2; tumor protein p53 binding protein, 2; p53凋亡刺激蛋白1;
背景信息:
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008],