靶标:
Sh3bp1
产品别名:
3BP-1; Sh3bp1; SH3-domain binding protein 1; SH3-domain binding protein 1; SH3 domain-binding protein 1; SH3结构域结合蛋白3;
背景信息:
function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.,sequence caution:Translated as Cys.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,