靶标：
Abcb1a
产品别名：
Abcb4； Evi32； Mdr1a； Mdr3； P-gp； Pgp； Pgy-3； Pgy3； mdr-3； Abcb1a； ATP-binding cassette, sub-family B (MDR/TAP), member 1A； ATP-binding cassette, sub-family B (MDR/TAP), member 1A； ATP-dependent translocase ABCB1； ATP-binding cassette sub-family B member 1A； ATP-binding cassette, sub-family B (MDR/TAP), member 4； ATP-binding cassette, subfamily B, member 1A； P-glycoprotein 3； ecotropic viral integration site 32； multi-drug resistance 3； multidrug resistance protein 3； multiple drug resistant 1a； phospholipid transporter ABCB1；
背景信息：
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
