靶标：
Sik1
产品别名：
Hrt-20； Msk； Sik； Sik-1； Snf1lk； Sik1； salt inducible kinase 1； salt inducible kinase 1； serine/threonine-protein kinase SIK1； Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase)； SNF1-like kinase； myocardial SNF1-like kinase； salt-inducible protein kinase 1； serine/threonine-protein kinase SNF1-like kinase 1； serine/threonine-protein kinase SNF1LK； 丝氨酸/苏氨酸蛋白激酶SIK1；
背景信息：
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,
