靶标:
KLF12
产品别名:
AP-2rep; AP2REP; HSPC122; KLF12; KLF transcription factor 12; KLF transcription factor 12; Krueppel-like factor 12; AP-2 repressor; AP-2rep transcription factor; KLF12 zinc finger transcriptional repressor; Kruppel like factor 12; transcriptional repressor AP-2rep; 锌指转录抑制因子KLF12;
背景信息:
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],