靶标：
NUDT5
产品别名：
YSA1； YSA1H； YSAH1； hNUDT5； NUDT5； nudix hydrolase 5； nudix hydrolase 5； ADP-sugar pyrophosphatase； 8-oxo-dGDP phosphatase； nuclear ATP-synthesis protein NUDIX5； nudix (nucleoside diphosphate linked moiety X)-type motif 5； NUDT5蛋白；
背景信息：
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013],
