靶标：
SPINK5
产品别名：
LEKTI； LETKI； NETS； NS； VAKTI； SPINK5； serine peptidase inhibitor Kazal type 5； serine peptidase inhibitor Kazal type 5； serine protease inhibitor Kazal-type 5； lympho-epithelial Kazal-type-related inhibitor； lymphoepithelial Kazal-type-related inhibitor； 丝氨酸肽酶抑制因子Kazal型5(SPINK5)； 丝氨酸蛋白酶抑制剂SPINK5；
背景信息：
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
