靶标:
CLP1
产品别名:
HEAB; hClp1; CLP1; cleavage factor polyribonucleotide kinase subunit 1; cleavage factor polyribonucleotide kinase subunit 1; polyribonucleotide 5'-hydroxyl-kinase Clp1; ATP/GTP-binding protein; cleavage and polyadenylation factor I subunit 1; homolog of yeast CFIA subunit Clp1p; polyadenylation factor Clp1; polynucleotide kinase Clp1; pre-mRNA cleavage complex II protein Clp1; 多聚腺苷酸因子Clp1蛋白;
背景信息:
This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],