靶标:
EDAR
产品别名:
DL; ECTD10A; ECTD10B; ED1R; ED3; ED5; EDA-A1R; EDA1R; EDA3; HRM1; EDAR; ectodysplasin A receptor; ectodysplasin A receptor; tumor necrosis factor receptor superfamily member EDAR; EDA-A1 receptor; anhidrotic ectodysplasin receptor 1; downless homolog; downless, mouse, homolog of; ectodermal dysplasia receptor; ectodysplasin 1, anhidrotic receptor; hypohidrotic ectodermal dysplasia; 肿瘤坏死因子受体超家族成员EDAR;
背景信息:
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008],