靶标:
MTHFS
产品别名:
HsT19268; NEDMEHM; MTHFS; methenyltetrahydrofolate synthetase; methenyltetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); methenyl-THF synthetase;
背景信息:
The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.