靶标：
DPYSL4
产品别名：
CRMP3； DRP-4； ULIP4； DPYSL4； dihydropyrimidinase like 4； dihydropyrimidinase like 4； dihydropyrimidinase-related protein 4； CRMP-3； ULIP-4； UNC33-like phosphoprotein 4； collapsin response mediator protein 3； 二氢嘧啶酶样蛋白4(DPYSL4)； 二氢嘧啶酶相关蛋白3；
背景信息：
disease:Antibodies against post-translationally modified DPYSL4, also called anti-CV2 autoantibodies, are present in sera from patients with paraneoplastic neurological diseases (PND). PND are disorders of the nervous system associated with various systemic cancers which are not a direct result of the tumor mass or metastasis, but attributed to remote effects of the cancer.,function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.,
