靶标：
DCTN2
产品别名：
DCTN50； DYNAMITIN； HEL-S-77； RBP50； DCTN2； dynactin subunit 2； dynactin subunit 2； dynactin subunit 2； 50 kDa dynein-associated polypeptide； dynactin 2 (p50)； dynactin complex 50 kDa subunit； epididymis secretory protein Li 77； epididymis secretory sperm binding protein； p50 dynamitin； 动力蛋白激活蛋白2；
背景信息：
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012],
