靶标:
HMG20B
产品别名:
BRAF25; BRAF35; HMGX2; HMGXB2; PP7706; SMARCE1r; SOXL; pp8857; HMG20B; high mobility group 20B; high mobility group 20B; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related; BRCA2-associated factor 35; HMG box domain containing 2; HMG box-containing protein 20B; HMG domain-containing protein 2; HMG domain-containing protein HMGX2; SMARCE1-related protein; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1-related; Sox-like transcriptional factor; structural DNA-binding protein BRAF35; 乳腺癌易感基因2相关蛋白; 高迁移率族蛋白20B(HMG20B);
背景信息:
function:Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.,sequence caution:Translation N-terminally extended.,similarity:Contains 1 HMG box DNA-binding domain.,subcellular location:Localized to condensed chromosomes in mitosis in conjunction with BRCA2.,subunit:Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein.,tissue specificity:Ubiquitously expressed in adult tissues.,