靶标:
OSBPL2
产品别名:
DFNA67; DNFA67; ORP-2; ORP2; OSBPL2; oxysterol binding protein like 2; oxysterol binding protein like 2; oxysterol-binding protein-related protein 2; OSBP-related protein 2; 氧固醇结合蛋白样2;
背景信息:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.