靶标：
ARHGEF11
产品别名：
GTRAP48； PDZ-RHOGEF； ARHGEF11； Rho guanine nucleotide exchange factor 11； Rho guanine nucleotide exchange factor 11； rho guanine nucleotide exchange factor 11； Rho guanine exchange factor (GEF) 11； Rho guanine nucleotide exchange factor (GEF) 11； RhoA-specific guanine nucleotide exchange factor； RhoGEF glutamate transport modulator； glutamate transporter EAAT4-associated protein 48； Rho鸟甘酸转运蛋白；
背景信息：
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
