靶标:
ST18
产品别名:
NZF-3; NZF3; ZC2H2C3; ZC2HC10; ZNF387; ST18; ST18 C2H2C-type zinc finger transcription factor; ST18 C2H2C-type zinc finger transcription factor; suppression of tumorigenicity 18 protein; ST18, C2H2C-type zinc finger; neural zinc finger transcription factor 3; suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); suppression of tumorigenicity 18, zinc finger; zinc finger protein 387; 肿瘤抑制蛋白18;
背景信息:
function:Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.,similarity:Contains 6 C2HC-type zinc fingers.,tissue specificity:Detected at low levels in heart, liver, kidney, skeletal muscel, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.,