靶标：
MDC1
产品别名：
NFBD1； MDC1； mediator of DNA damage checkpoint 1； mediator of DNA damage checkpoint 1； mediator of DNA damage checkpoint protein 1； homologue to Drosophila photoreceptor protein calphotin； nuclear factor with BRCT domains 1； DNA损伤关卡蛋白1；
背景信息：
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008],
