靶标：
ADAMTS4
产品别名：
ADAMTS-2； ADAMTS-4； ADMP-1； ADAMTS4； ADAM metallopeptidase with thrombospondin type 1 motif 4； ADAM metallopeptidase with thrombospondin type 1 motif 4； A disintegrin and metalloproteinase with thrombospondin motifs 4； ADAM-TS 4； ADAM-TS4； a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4； aggrecanase-1； epididymis secretory sperm binding protein； 血小板反应蛋白解整合素金属肽酶4(ADAMTS4)；
背景信息：
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradatio
