靶标：
MED23
产品别名：
ARC130； CRSP130； CRSP133； CRSP3； DRIP130； MRT18； SUR-2； SUR2； MED23； mediator complex subunit 23； mediator complex subunit 23； mediator of RNA polymerase II transcription subunit 23； 130 kDa transcriptional co-activator； 133 kDa transcriptional co-activator； activator-recruited cofactor 130 kDa component； cofactor required for Sp1 transcriptional activation subunit 3； vitamin D3 receptor interacting protein； 多巴胺受体相互作用蛋白1； 转录共激活因子130；
背景信息：
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012],
