靶标：
CNOT8
产品别名：
CAF1； CALIF； Caf1b； POP2； hCAF1； CNOT8； CCR4-NOT transcription complex subunit 8； CCR4-NOT transcription complex subunit 8； CCR4-NOT transcription complex subunit 8； CAF1-like protein； CAF2； CALIFp； CCR4-associated factor 8； PGK promoter directed over production； 细胞表面趋化因子受体4相关蛋白8；
背景信息：
Has 3'-5' poly(A exoribonuclease activity for synthetic poly(A RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
