靶标：
ATP6V1F
产品别名：
ATP6S14； VATF； Vma7； ATP6V1F； ATPase H+ transporting V1 subunit F； ATPase H+ transporting V1 subunit F； V-type proton ATPase subunit F； ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F； ATPase, vacuolar, 14 kD； H(+)-transporting two-sector ATPase, 14kD subunit； V-ATPase 14 kDa subunit； V-ATPase F subunit； V-ATPase subunit F； adenosinetriphosphatase 14k chain； vacuolar ATP synthase subunit F； vacuolar proton pump F subunit； vacuolar proton pump subunit F；
背景信息：
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 20
