靶标:
ZBED1
产品别名:
ALTE; DREF; TRAMP; hDREF; ZBED1; zinc finger BED-type containing 1; zinc finger BED-type containing 1; E3 SUMO-protein ligase ZBED1; Ac-like transposable element; BED-type zinc finger domain-containing protein 1; DNA replication-related element binding factor; dREF homolog; zinc finger BED domain-containing protein 1; DNA复制相关元件结合因子;
背景信息:
This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.