靶标：
CBFA2T2
产品别名：
EHT； MTGR1； ZMYND3； p85； CBFA2T2； CBFA2/RUNX1 partner transcriptional co-repressor 2； CBFA2/RUNX1 partner transcriptional co-repressor 2； protein CBFA2T2； CBFA2/RUNX1 translocation partner 2； ETO homolog on chromosome 20； ETO homologous on chromosome 20； MTG8-like protein； MTG8-related protein 1； core-binding factor, runt domain, alpha subunit 2; translocated to, 2； myeloid translocation gene-related protein 1； myeloid translocation-related protein 1； 髓易位基因相关蛋白1；
背景信息：
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
