靶标：
MCM3AP
产品别名：
GANP； MAP80； PNRIID； SAC3； MCM3AP； minichromosome maintenance complex component 3 associated protein； minichromosome maintenance complex component 3 associated protein； germinal-center associated nuclear protein； 80 kDa MCM3-associated protein； MCM3 acetylating protein； MCM3 acetyltransferase； MCM3 import protein； MCM3 minichromosome maintenance deficient 3 associated protein； germinal center-associated nuclear protein； germinal-centre associated nuclear protein； 生发中心相关核蛋白MCM3；
背景信息：
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014],
