靶标：
NR1I2
产品别名：
BXR； ONR1； PAR； PAR1； PAR2； PARq； PRR； PXR； SAR； SXR； NR1I2； nuclear receptor subfamily 1 group I member 2； nuclear receptor subfamily 1 group I member 2； nuclear receptor subfamily 1 group I member 2； orphan nuclear receptor PAR1； orphan nuclear receptor PXR； pregnane X receptor； steroid and xenobiotic receptor； 孕烷X受体(PXR)； 孤儿核受体PAR1；
背景信息：
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008],
