靶标：
AKR7A2
产品别名：
AFAR； AFAR1； AFB1-AR1； AKR7； AKR7A2； aldo-keto reductase family 7 member A2； aldo-keto reductase family 7 member A2； aflatoxin B1 aldehyde reductase member 2； AFB1 aldehyde reductase 1； AFB1-AR 1； HEL-S-166mP； SSA reductase； aflatoxin aldehyde reductase； aflatoxin beta1 aldehyde reductase； aldoketoreductase 7； epididymis secretory sperm binding protein Li 166mP； succinic semialdehyde reductase； 醛固酮类还原酶家族7成员A2；
背景信息：
Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene. It is mapped to 1p36.13. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family,which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein,thought to be localized in the golgi,catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator,gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.
