靶标：
CILP
产品别名：
CILP-1； HsT18872； CILP； cartilage intermediate layer protein； cartilage intermediate layer protein； cartilage intermediate layer protein 1； cartilage intermediate layer protein 1 C1； cartilage intermediate layer protein 1 C2； cartilage intermediate layer protein, nucleotide pyrophosphohydrolase； 软骨中间层蛋白(CILP)； 软骨中间层蛋白CILP；
背景信息：
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010],
