靶标：
PLA2G7
产品别名：
LDL-PLA2； LP-PLA2； PAFAD； PAFAH； PLA2G7； phospholipase A2 group VII； phospholipase A2 group VII； platelet-activating factor acetylhydrolase； 1-alkyl-2-acetylglycerophosphocholine esterase； 2-acetyl-1-alkylglycerophosphocholine esterase； LDL-PLA(2)； LDL-associated phospholipase A2； PAF 2-acylhydrolase； PAF acetylhydrolase； gVIIA-PLA2； group-VIIA phospholipase A2； lipoprotein-associated phospholipase A2； phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)； 脂蛋白关联磷脂酶A2(LpPLA2)； 脂蛋白磷脂酶A2；
背景信息：
Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDa protein of 441 amino acids. It is one of several PAF acetylhydrolases. In the blood it travels mainly with low-density lipoprotein (LDL). Less than 20% is associated with high-density lipoprotein HDL. It is an enzyme produced by inflammatory cells and hydrolyzes oxidized phospholipids in LDL. Lp-PLA2 is platelet-activating factor (PAF) acetylhydrolase, a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate.
