靶标：
UBE2D2
产品别名：
E2(17)KB2； PUBC1； UBC4； UBC4/5； UBCH4； UBCH5B； UBE2D2； ubiquitin conjugating enzyme E2 D2； ubiquitin conjugating enzyme E2 D2； ubiquitin-conjugating enzyme E2 D2； (E3-independent) E2 ubiquitin-conjugating enzyme D2； E2 ubiquitin-conjugating enzyme D2； p53-regulated ubiquitin-conjugating enzyme 1； ubiquitin carrier protein D2； ubiquitin conjugating enzyme E2D 2； ubiquitin-conjugating enzyme E2-17 kDa 2； ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)； ubiquitin-protein ligase D2； 泛素蛋白连接酶D2；
背景信息：
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013],
