靶标：
UBE2D1
产品别名：
E2(17)KB1； SFT； UBC4/5； UBCH5； UBCH5A； UBE2D1； ubiquitin conjugating enzyme E2 D1； ubiquitin conjugating enzyme E2 D1； ubiquitin-conjugating enzyme E2 D1； (E3-independent) E2 ubiquitin-conjugating enzyme D1； E2 ubiquitin-conjugating enzyme D1； UBC4/5 homolog； stimulator of Fe transport； ubiquitin carrier protein D1； ubiquitin conjugating enzyme E2D 1； ubiquitin-conjugating enzyme E2(17)KB 1； ubiquitin-conjugating enzyme E2-17 kDa 1； ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)； ubiquitin-protein ligase D1； 泛素蛋白连接酶D1；
背景信息：
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011],
