靶标:
RO60
产品别名:
RORNP; SSA2; TROVE2; RO60; Ro60, Y RNA binding protein; Ro60, Y RNA binding protein; RNA-binding protein RO60; 60 kDa ribonucleoprotein Ro; Ro/SSA 60kDa; Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro); TROVE domain family member 2; gastric cancer multi-drug resistance protein; ro60 autoantigen; sjoegren syndrome type A antigen; 干燥综合征抗原A2(SSA2); 干燥综合征相关蛋白2;
背景信息:
disease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign.,function:RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the Ro 60 kDa family.,similarity:Contains 1 TROVE domain.,subunit:Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.,