靶标:
SLIT1
产品别名:
MEGF4; SLIL1; SLIT-1; SLIT3; SLIT1; slit guidance ligand 1; slit guidance ligand 1; slit homolog 1 protein; multiple EGF-like domains protein 4; multiple epidermal growth factor-like domains protein 4; slit homolog 1; Slit同源物1(Slit1); 多重表皮生长因子样蛋白4;
背景信息:
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.