靶标:
SETMAR
产品别名:
METNASE; Mar1; SETMAR; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion gene; histone-lysine N-methyltransferase SETMAR; SET domain and mariner transposase fusion gene-containing protein; SET domain and mariner transposase fusion protein; 组蛋白赖氨酸N-甲基SETMAR;
背景信息:
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],