靶标:
SAA1
产品别名:
PIG4; SAA; SAA2; TP53I4; SAA1; serum amyloid A1; serum amyloid A1; serum amyloid A-1 protein; serum amyloid A protein; tumor protein p53 inducible protein 4; 血清淀粉样蛋白A; 血清淀粉样蛋白A(SAA);
背景信息:
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. [provided by RefSeq, Feb 2016],