靶标:
RGS7
产品别名:
RGS7; regulator of G protein signaling 7; regulator of G protein signaling 7; regulator of G-protein signaling 7; regulator of G-protein signaling RGS7; regulator of G-protein signalling 7; G蛋白信号转导调节因子7; 蛋白信号调节因子7(RGS7);
背景信息:
function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations.,PTM:Palmitoylated.,PTM:Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity.,similarity:Contains 1 DEP domain.,similarity:Contains 1 G protein gamma domain.,similarity:Contains 1 RGS domain.,subunit:Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP.,