靶标:
RFC2
产品别名:
RFC40; RFC2; replication factor C subunit 2; replication factor C subunit 2; replication factor C subunit 2; A1 40 kDa subunit; RF-C 40 kDa subunit; activator 1 subunit 2; replication factor C (activator 1) 2, 40kDa; 复制激活因子C2;
背景信息:
This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013],