靶标:
REST
产品别名:
DFNA27; GINGF5; HGF5; NRSF; WT6; XBR; REST; RE1 silencing transcription factor; RE1 silencing transcription factor; RE1-silencing transcription factor; neural-restrictive silencer factor; neuron restrictive silencer factor; repressor binding to the X2 box; 神经元抑制蛋白;
背景信息:
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes.