靶标：
RBBP4
产品别名：
NURF55； RBAP48； lin-53； RBBP4； RB binding protein 4, chromatin remodeling factor； RB binding protein 4, chromatin remodeling factor； histone-binding protein RBBP4； CAF-1 subunit C； CAF-I 48 kDa subunit； CAF-I p48； MSI1 protein homolog； RBBP-4； chromatin assembly factor 1 subunit C； chromatin assembly factor I p48 subunit； chromatin assembly factor/CAF-1 p48 subunit； nucleosome-remodeling factor subunit RBAP48； retinoblastoma-binding protein 4； retinoblastoma-binding protein p48； 视网膜母细胞瘤结合蛋白P48；
背景信息：
Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene. This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. And it is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.
