靶标:
RARB
产品别名:
HAP; MCOPS12; NR1B2; RARbeta; RARbeta1; RRB2; RARB; retinoic acid receptor beta; retinoic acid receptor beta; retinoic acid receptor beta; HBV-activated protein; RAR-beta; RAR-epsilon; hepatitis B virus activated protein; nuclear receptor subfamily 1 group B member 2; retinoic acid receptor, beta polypeptide; 维甲酸受体β; 维甲酸受体β(RARb);
背景信息:
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014],