靶标:
PZP
产品别名:
CPAMD6; PZP; PZP alpha-2-macroglobulin like; PZP alpha-2-macroglobulin like; pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6; Pregnancy zone protein; pregnancy-zone protein; 妊娠区带蛋白PZP; 妊娠带蛋白(PZP);
背景信息:
The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients.