靶标：
NECTIN1
产品别名：
CD111； CLPED1； ED4； HIgR； HV1S； HVEC； OFC7； PRR； PRR1； PVRL1； PVRR； PVRR1； SK-12； nectin-1； NECTIN1； nectin cell adhesion molecule 1； nectin cell adhesion molecule 1； nectin-1； ectodermal dysplasia 4 (Margarita Island type)； herpes simplex virus type 1 sensitivity； herpes virus entry mediator C； herpesvirus Ig-like receptor； nectin 1； poliovirus receptor-like 1； poliovirus receptor-related 1 (herpesvirus entry mediator C)； poliovirus receptor-related protein 1； 脊髓灰质炎受体相关蛋白1； 脊髓灰质炎病毒受体相关分子1(PVRL1)；
背景信息：
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009],
