靶标：
PTPRO
产品别名：
GLEPP1； NPHS6； PTP-OC； PTP-U2； PTPROT； PTPU2； R-PTP-O； PTPRO； protein tyrosine phosphatase receptor type O； protein tyrosine phosphatase receptor type O； receptor-type tyrosine-protein phosphatase O； PTP phi； PTPase U2； glomerular epithelial protein 1； osteoclastic transmembrane protein-tyrosine phosphatase； phosphotyrosine phosphatase U2； protein tyrosine phosphatase PTP-U2； 肾小球上皮蛋白1； 蛋白酪氨酸磷酸酶受体O(PTPRO)；
背景信息：
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
