靶标：
PTPRN2
产品别名：
IA-2beta； IAR； ICAAR； PTPRP； R-PTP-N2； PTPRN2； protein tyrosine phosphatase receptor type N2； protein tyrosine phosphatase receptor type N2； receptor-type tyrosine-protein phosphatase N2； IAR/receptor-like protein-tyrosine phosphatase； islet cell autoantigen-related protein； phogrin； protein tyrosine phosphatase receptor pi； protein tyrosine phosphatase, receptor type, N polypeptide 2； tyrosine phosphatase IA-2 beta； 胰岛细胞自身抗原相关蛋白PTPRN2； 蛋白酪氨酸磷酸酶受体N2(PTPRN2)；
背景信息：
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
