靶标:
PTPRB
产品别名:
HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP; PTPRB; protein tyrosine phosphatase receptor type B; protein tyrosine phosphatase receptor type B; receptor-type tyrosine-protein phosphatase beta; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypeptide; vascular endothelial protein tyrosine phosphatase; 蛋白酪氨酸磷酸酶受体B(PTPRB); 蛋白酪氨酸磷酸酶受体PTPRB;
背景信息:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite gro