靶标：
PSMD7
产品别名：
MOV34； P40； Rpn8； S12； PSMD7； proteasome 26S subunit, non-ATPase 7； proteasome 26S subunit, non-ATPase 7； 26S proteasome non-ATPase regulatory subunit 7； 26S proteasome regulatory subunit S12； 26S proteasome regulatory subunit rpn8； Moloney leukemia virus-34 proviral integration； Mov34 homolog； proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)； proteasome subunit p40； 蛋白酶调解因子7； 非ATP酶蛋白酶体26S亚基7(PSMD7)；
背景信息：
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
