靶标：
PSMD3
产品别名：
P58； RPN3； S3； TSTA2； PSMD3； proteasome 26S subunit, non-ATPase 3； proteasome 26S subunit, non-ATPase 3； 26S proteasome non-ATPase regulatory subunit 3； 26S proteasome regulatory subunit RPN3； 26S proteasome regulatory subunit S3； proteasome (prosome, macropain) 26S subunit, non-ATPase, 3； proteasome subunit p58； tissue specific transplantation antigen 2； 蛋白酶体PSMD3；
背景信息：
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012],
