靶标：
PSMC4
产品别名：
MIP224； RPT3； S6； TBP-7； TBP7； PSMC4； proteasome 26S subunit, ATPase 4； proteasome 26S subunit, ATPase 4； 26S proteasome regulatory subunit 6B； 26S protease regulatory subunit 6B； 26S proteasome AAA-ATPase subunit RPT3； MB67-interacting protein； Tat-binding protein 7； protease 26S subunit 6； proteasome (prosome, macropain) 26S subunit, ATPase, 4； ATP酶蛋白酶体26S亚基4(PSMC4)； Tat结合蛋白7；
背景信息：
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
