靶标：
PRG2
产品别名：
BMPG； MBP； MBP1； proMBP； PRG2； proteoglycan 2, pro eosinophil major basic protein； proteoglycan 2, pro eosinophil major basic protein； bone marrow proteoglycan； eosinophil granule major basic protein； eosinophil major basic protein； natural killer cell activator； proteoglycan 2 preproprotein； proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)； 嗜酸性粒细胞颗粒关键碱性蛋白；
背景信息：
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
