靶标:
PPM1B
产品别名:
PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B; protein phosphatase, Mg2+/Mn2+ dependent 1B; protein phosphatase 1B; protein phosphatase 2C-like protein; 蛋白质磷酸酶1B;
背景信息:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008],